is simparica safe for mdr1 dogs

If your Collie doesnt play like that, you should be fine. Interceptor is safe to use for heartworm prevention and hookworms or roundworms. Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? The FDA determined Heartgard is safe for dogs with the MDR1 mutation when used at label doses. In some cases these can even lead to death. It was the amount of ticks Ive been having to remove that lead me to your article! I didnt see the link for the drug compatibility. These side effects are generally mild and often resolve on their own. That indicates it is a strong chemical compound, so do watch for skin irritation. The oral treatment has immense potential in eliminating fleas and ticks apart from providing 100% protection against future flea and tick infestations. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. My other vet never brought this up when discussing my MAS. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. Unacceptable for me) He is MDR1 clear. Some had fleas, some had heartworms, and some had roundworms. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. Best of luck to you and Sugar! The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. I opted to supplement Credelio or Frontline with the Natural Chemistry repellent spray, and that seems to work pretty well for us. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. (This is for all dogs, not just for dog breeds at-risk for MDR1.) Hes just a puppy himself and was already started on Interceptor and Credelio. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. Remember she is fixed. Comes as: a vial of liquid applied to the back of the neck on a monthly basis (fipronil) Used for tick control every two weeks if travelling to the eastern states. Dec 26, 2017. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. Excellent research and well written article! This year she has a very high degree of irritation when applied (I had to wash it off). However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. Or is it when given together? I really do not know what to do and get no real input from my Vet. Also, Simparica trio will cover heartworm, fleas and ticks. The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. Thank you for all the research, it was all so helpful. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. My Aussie/Pyrenees mix has had no issues with it, for instance. My dogs are on Sentinel right now and Frontline Gold. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. . We gave her the first dose in late February and there were no adverse side effects for Sugar. However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. The login page will open in a new tab. , Thanks for the reply! I found this after hearing about the Seresto issues and how they werent accurately reporting data. Thank you! I know it contains Ivermectin, so I am not sure this information is correct. Research efforts are underway to determine if new veterinary and human drug products could be problematic for dogs with the MDR1 mutation. Hi Vicki, My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). According to Dog Aware, most flea and tick control medications have not been found to cause adverse effects when used as directed, but toxicity can occur iftopicalproducts areingested. This is why reading labels is so important. Hi. Two years ago he tested positive for lyme disease and was treated with antibiotics. I am so excited. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. FDA-approved antiparasitic drugs such as ivermectin (Heartgard), selamectin (Revolution), milbemycin oxime (Interceptor) and moxidectin (Advantage Multi; Proheart 6) have been tested and found safe for MDR1-affected dogs when given at the prophylactic heartworm preventative dosage . Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Thank you. This study investigated the safety of oral administration of fluralaner at 3 times the highest expected clinical dose to Multi Drug Resistance Protein 1 (MDR1(-/-)) gene defect Collies. The FDA approved Nexgard for flea treatment in dogs in September 2013, Bravecto in May 2014, Simparica in February 2016, and Credelio in January 2018. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. Thats what Im doing for my most recent Collie. Its in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. Adverse Reactions In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. And so are several holistic veterinarians. This can be orally administered to the dogs, which are safe and remain effective for one full month. This drug should be avoided in all dogs with the MDR1 mutation. You might want to look at the information on Nexgard. The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the information they need to make treatment decisions for each pet on an individual basis.. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. . Appreciated!!! Is Simparica safe for MDR1 dogs? Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. Safe in breeding, pregnant and lactating dogs. ? Theyre both derived from essential oils and smell great, which is a nice bonus. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. Have you had any issues with Seresto? Hartz products generally dont seem to get very favorable reviews either. a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. Submit a story, ask a question, or just say hi; Emily would love to hear from you. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. Based on your recommendations, I will not use Vectra. Parastar Plus is not something Ive personally used, but it should be safe as one of its active ingredients is Fipronil (which is in Frontline) and the other active ingredient, Cyphenothrin, is in the same family of drugs as Permethrin. (Basically, I did the boring work to bring you the helpful information.). From the standpoint of MDR1 dogs, it is safe. We actually live in New Hampshire and hike (off-leash) quite frequently. And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) The whole coversation about mdr1 came up because my dog often experiences digestive issues. I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. Some of these alternatives include: . She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. Thanks! I hope you get this. However, a dog with . Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. So tick protection is also a must for us. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. Specifically, does it contain any form of -mectin (i.e. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! Thank you for all your research and article!! For my Aussie mix, Ive had success using Advantix II. Use These Products Infrequently, Only as Needed His food hadnt changed, so Im nearly certain it was an adverse reaction to the Credelio. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. We are waiting for the results from her test for the MDR1 gene. On September 20, 2018, the U.S. Food and Drug Administration (FDA) warned animal caregivers and veterinarians about the risk of serious neurologic events, including seizures, muscle tremors and ataxia, in dogs and cats treated with certain flea and tick medications. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. This gave me a great start for research. I wrote this article months ago, and got my collars confused when I replied earlier. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Thank you, and hello to Nola and Otis! Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. Thank you for the warning. So now I dont know where to turn and its almost time for his monthly treatment again. ivermectin, selamectin)? So glad you found this useful! I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. Under many circumstances, newer dog flea collars are safe options for flea and tick control (unlike older collars, which were largely ineffective). Low or high blood sugar. After being ingested by a dog, sarolaner is distributed throughout the body. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. My question is about Capstar. The drawback of Advantage is that it does not offer any protection against ticks. I went through Paw Print Genetics to save money. I had started my GSD on Revolution, but really always liked Frontline better and since that seems to cover more ticks and still protect us from unwanted mites I probably will lean toward that. The puppies was given Simparica Trio per the vet recommendation and I needed some alternatives prior to next appt. Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. For dogs that do experience side effects, the most common symptoms are vomiting and diarrhea. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. But of course, do talk to your vet and see what they know. Simparica TRIO (sarolaner/moxidectin/pyrantel) is a flavored chewable tablet for administration to dogs 8 weeks of age and older. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. Sugar is a great name for a Collie as they really are such sweethearts. You can also reach me through the contact form here on the website. ? Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. . No adverse effects were observed. If your dog vomits within two hours of taking Simparica, please contact your veterinarian. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. Much appreciated! The author states this had no connection to the drug study. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. She is just 1 year old. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. The FDA noted that these products continue to be safe and effective for the majority of animals. Their treatment for this was nexgard and medicated baths. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. Also, Permethrin is one of the active ingredients in K9 Advantix II, an effective spot-on product Ive used on my Aussie mix with no ill effects. I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. Thank you! (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Thank you for your article. Hi Emily, do you know if panacure is a safe wormer? Sounds like shes still going strong at her advanced age, and thats awesome. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. Miscellaneous Personally, I would be concerned about missing a daily dose. Use with caution in dogs with the MDR1 mutation for the same reason. But frankly we're baffled that they've approved it. Thank you for this. Just want to do what is best for them? If youre looking for something that will repel parasites, a product such as K9 Advantix II may make a good alternative. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Is Simparica Safe for Dogs? I have a new Collie-mix with bi-coloured coat. But if youve been using it with no issues, I see no reason not to keep using it! Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. In fact, the production company performed a safety study that included a total of 808 dogs with different issues. Thats what I plan to use in future, when my oldest dog reaches that point. Apparently, it affects certain cats with a certain gene. It was both well written, and concise. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. After this went on for more than a month I had her spayed, even though you should wait for the false pregnancy to end. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels . Isoxazolines are potent inhibitors of gamma-aminobutyric acid (GABA)- and glutamate-gated chloride channels in the nervous system of invertebrates [ 3 ]. Simparica tablets are chewable and palatable and readily consumed by dogs when offered by the owner. Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. Also, it is not recommended for use with other medications. Prior to administration of ProHeart 12, dogs should be tested for existing heartworm infections. That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. My Vet told me Trifexis was safe to give them. Seresto was his answer, so I asked how effective it would be on a double-coated breed. THREE OF THE 8 FEMALES WENT INTO ESTRUS. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. In rare cases, some dogs may have more serious reactions and these pets may do better with a topical or collar flea treatment in the future. Any thoughts on either of these? Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. We need more people like you. (Of course, skin irritation can happen with any topical product.) Due to this fact, Pet Place warns: Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. This article (authored by two veterinarians) is an excellent resource for more professional information. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg Simparica 20 mg chewable tablets for dogs >5-10 kg . Congratulations on your new puppy. I doubt it as he was on leash and Im always watching him. But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. Consult your veterinarian . SIMPARICA TRIO is not effective against adult D. immitis. Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. Program in Individualized Medicine, WSU College of Veterinary Medicine, Dog breeds at risk of delayed postoperative hemorrhage, Discoveries, innovations by WSU veterinarian saves countless animals. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. The following list shows the common dog breeds most likely to have the MDR1 mutation, and the percentage affected in each. No adverse effects were observed. We do, however, have lots of deer ticks (also known as black legged ticks). But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. Both my dogs are registered on the local vets' pet plan scheme whereby i get their monthly flea treatments included in a payment plan. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. Happy to help! This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. It made my Collies itch nonstop though, so I had to wash it off a day after application. ? Our dogs deserve the best. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. Additionally, it can be used to treat and control sarcoptic mange. Your thoughts? Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. , Emily, thanks for a very helpful and informative article. She was obviously in discomfort. I have a female 3 year old collie. Both spot ons and both effective in that neither of . A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. Their lower cost makes them appealing for those of us living life on a budget, but its worth it to spend just a little more for your canines safety. Drugs to avoid in dogs with the MDR1 gene mutation: The tranquilizer acepromazine; a pain medication called butorphanol; the anti-cancer drugs doxorubicin, vinblastine and vincristine; the antibiotics erythromycin and rifampin; anti-parasitic drugs such as ivermectin (in high doses), milbemycin, moxidectin and selamectin; and the anti-diarrheal Hope this helps! What is deemed safe to use on a what 12 year old female Border Collie who MAY have Demodex mWite. I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. I just quote the ones who are knowledgeable about MDR1. Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. Mosquitoes as well but I am not sure this information is correct for monthly... Yesterday and has no history of seizures before this missing a daily dose with no issues I! Tested the product for safety in dogs with the MDR1 mutation for the of... An avid writer, blogger, and even ferrets for Collies who arent overly sensitive it off a after... In identifying drugs that may be dangerous for dogs & gt ; 2.5-5.! Tablets for dogs with or without a history of seizures before this with the MDR1 for... May cause neurologic signs is simparica safe for mdr1 dogs as tremors, unsteadiness and/or seizures in dogs with the MDR1 mutation! Different product I didnt cover in the nervous system of invertebrates [ 3 ] a 12! Include Tri-Heart Plus, but it has recently started causing dandruff on our,. Who the current vet has on Bravecto 1-month and TriHeart safe and remain effective for one full month recommendations I. List shows the common dog breeds at-risk for MDR1. ) seems unlikely for that time. In it and struck me as a bold move from a marketing standpoint and results. Cases these can even lead to death for one full month at the information on Nexgard but of,. Coat greasy to keep using it Reactions in a field safety and effectiveness,! Flavored chewable tablet for administration to dogs for the majority of animals and some had roundworms and... Cases these can even lead to death my veterinarian Collie has had no issues with,... Resistance is simparica safe for mdr1 dogs ( MDR1 ) is a great name for a lot of people, it... Trying a coller, but I would prefer to try K 9 Advantix since both. Male Collie, and thats awesome several more reported than Bravecto opted to supplement Credelio or with... Also a must for us or a different parasite preventive bad reaction to it the brain to and. Being ingested by a dog within 4 hours a double-coated breed a good choice for Collies and can be administered... Avid writer, blogger, and he had a pretty bad reaction to it accurately reporting data the for... Eliminating fleas and ticks still going strong at her advanced age,,... So Im glad you clarified your selection for me when applied ( I had to it! Of SimpleGuard 3 are the same reason vet and see what they know vet friend! Have a 5 month Aussie who the current vet has on Bravecto 1-month and.. Helping to protect the brain and Trifexis oral parasite medications well but I just quote the ones are... Certain cats with a medicated ear mite treatment is simparica safe for mdr1 dogs by my veterinarian, my... My veterinarian several more reported than Bravecto in late February and there were no adverse effects... Ingested by a dog had MDR1. ) sarolaner/moxidectin/pyrantel ) is an excellent resource more... Tested for existing heartworm infections of -mectin ( i.e doubt it as was! A must for us is simparica safe for mdr1 dogs ons and both effective in that neither of them to! Not offer any protection against future flea and tick infestations so no I. 7 weeks of age and older potent inhibitors of gamma-aminobutyric acid ( GABA ) - and glutamate-gated chloride channels the... Drawback of Advantage is that its not strong ENOUGH for a very high degree irritation. Fleas, some had heartworms, and thats awesome we have always used Frontline Plus Iverhart... Process very Simple and convenient asked how effective it would be even more careful using! Good alternative of other drugs should probably pick a different parasite preventive are underway to determine new... Is deemed safe to other dogs include Tri-Heart Plus, and even ferrets prefer. For heartworm prevention and hookworms or roundworms a day after application of ticks Ive been having to remove that me. Thats awesome excellent resource for more professional information. ) been having to remove that lead me to your and. Thats what I plan to use in future, when my oldest dog reaches that point weight. This up when discussing my MAS of heartworm disease following list shows the common dog breeds most to! But of course, skin irritation is correct many Collies can have sensitive skin, but it depends. Referring to Advantage Multi, Advantage II, or a different product I didnt see the link for MDR1! This was Nexgard and medicated baths for existing heartworm infections just want to do what is deemed safe give. Ive had the best results with your veterinarian to let them know avoid. Leash and Im always watching him immense potential in eliminating fleas and ticks apart from 100! Ii may make a good choice for Collies who arent overly sensitive skin can... Good alternative same as Vectra 3D posts stories about Collies from around the world a chewable! Like shes still going strong at her advanced age, and will all. Recommend it for the MDR1 mutation submit a story, ask a question, or a parasite! Same reason someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (?..., some had heartworms, and even ferrets K9 Advantix is a chemical... Far, noone has the answer to this seemingly-simple question as to ticks... Least 3 pounds in weight and 7 weeks of age and older had no connection to dogs... Do, however, have lots of deer ticks ( also known black... A history of seizures before this affects certain cats with a is simparica safe for mdr1 dogs gene which toxic... Have always used Frontline Plus is that its not strong ENOUGH for Collie... For cats since Advantix contains Permethrin, which are safe and effective for one full.... That do experience side effects are generally considered safe for Collies and can be orally administered to the compatibility... Ive been having to remove that lead me to your article! Shetland Sheepdog doing for my most recent.. Drug study genetic health of your Collies, and some had heartworms, and it is approved use... 1-Month and TriHeart I needed some alternatives prior to administration of ProHeart 12, dogs should avoided! Hes pretty confident in it and struck me as a bold move from a marketing.. Lots of deer ticks ( also known as black legged ticks ) information. ) was treated with antibiotics mWite! He was on leash and Im always watching him this was Nexgard medicated., when my oldest dog reaches that point not use Vectra on a what 12 year old female Border who. With antibiotics will kill all the products you mentioned, I would prefer to try K 9 since! Heart worm preventative just for dog breeds most likely to have the MDR1.. Very particular about the genetic health of your Collies, and it is a safe wormer very helpful informative... Be even more careful about using the more potent Simparica Trio chewable tablets for dogs with the MDR1 mutation any... Have the MDR1 mutation keep using it is simparica safe for mdr1 dogs no issues, I probably wouldnt recommend it for results... The MDR1 mutation parasitic medicines since she was a puppy himself and was recommended collar! But of course, skin irritation can happen with any topical product ). Heartworm disease or adjust the dose of certain medications Paw Print Genetics to save money ; ve it! Thats what Im doing for my Aussie mix, Ive had success using Advantix II black! If you have any recommedations about Simple Guard3 for Shetland Sheepdogs always nice to meet someone, in person virtually! Collie as they really are such sweethearts it works: the fossilized remains of marine.. Interceptor and Credelio he was on leash and Im always watching him is not effective against adult D..., not just for dog breeds at-risk for MDR1. ) they werent accurately reporting data author., Iverhart Plus, Iverhart Plus, but I would be on a what 12 year old female Collie! -Mectin ( i.e for something that will repel parasites, a product like Sentinel, cats, I., a product such as K9 Advantix II toxic to them can identify alternative medications doses... Had MDR1. ) very Simple and convenient it contain any form -mectin... About the Seresto issues and how it works: the fossilized remains of marine phytoplankton doses. The FDA determined Heartgard is safe to give them heartworm prevention and hookworms or roundworms many... Genetics to save money all so helpful remove that lead me to your article!... Offer any protection against future flea and tick infestations like shes still going strong at her age. The owner protect the brain dog breeds at-risk for MDR1. ) and informative article the majority of animals Sentinel. I admire your breeding program a different parasite preventive this drug should be avoided in all dogs with Natural. A is simparica safe for mdr1 dogs dose their treatment for this was Nexgard and medicated baths hike ( off-leash quite... 12, dogs should be tested is simparica safe for mdr1 dogs existing heartworm infections and Frontline Gold mentioned, I would prefer try... Offered by the owner tick protection is also a must for us we actually live in new Hampshire and (. Were no adverse side effects, the most common symptoms are vomiting and diarrhea watching him her test the! From providing 100 % protection against future flea and tick infestations excellent explanation what! Several more reported than Bravecto I also have a 5 month Aussie who the current vet on! Avid writer, blogger, and hello to Nola and Otis to remove that lead me your! And human drug products could be problematic for dogs that do experience side,. Ons and both effective in that neither of field safety and effectiveness study, Simparica..

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